PF3D7_0925600

Genome location: Pf3D7_09_v3:1,026,711..1,028,500(+)

Genome classification: Core

Function and Localization

Product Description: zinc binding protein (Yippee), putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.01	1.00
Trophozoite	expressed	0.06	0.96
Schizont	expressed	0.07	0.95
Gametocyte	expressed	0.20	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0925600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.591 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0826400)

Relative Growth Rate: 0.96 ± 0.12
Confidence: 5.60

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0826400)

Modification: Disrupted | RMgm-2418

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2Q2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100480

Most Similar Human Ortholog: P61236

TM-align score: 0.83 | RMSD: 1.58

Seq Identity: 0.43 | Length: 105 / 128

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000090238	yippee like 3
ENSG00000100027	yippee like 1
ENSG00000119801	yippee like 5
ENSG00000166793	yippee like 4
ENSG00000175155	yippee like 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 142

Non-coding: 135 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 128 | Molecular Weight (kDa): 14.765

UniProt ID(s): Q8I2Q2

PDB ID(s): None

Isoelectric Point: 6.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004910	Yippee/Mis18/Cereblon
InterPro	IPR039058	Yippee family
PFam	PF03226	Yippee/Mis18/Cereblon
Superfamily	N/A	N/A