Genome location: Pf3D7_09_v3:1,033,046..1,039,152(+)
Genome classification: Core
Product Description: regulator of nonsense transcripts 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0035145 | exon-exon junction complex |
| Component | GO:0005844 | polysome |
| Process | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.23 | 0.89 |
| Trophozoite | expressed | 1.08 | 0.46 |
| Schizont | expressed | 0.31 | 0.82 |
| Gametocyte | expressed | 1.02 | 0.48 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0925800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.419 | #Insertions: 12
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2Q1
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=1.50) with 6JWQ (Global RMSD=15.67)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103377
Most Similar Human Ortholog: Q9HAU5
TM-align score: 0.25 | RMSD: 9.26
Seq Identity: 0.05 | Length: 475 / 1754
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000151461 | UPF2 regulator of nonsense mediated mRNA decay |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 71 | 48 | 92 |
| disruptive | 90 | 198 | 120 | 311 |
| missense | 47 | 139 | 102 | 233 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 27 | 156 | 53 | 110 |
| disruptive | 141 | 481 | 213 | 485 |
| missense | 73 | 333 | 147 | 291 |
PlasmoDB Total SNPs: 289
Non-coding: 61 | Synonymous: 115 | Nonsynonymous: 112 | Stop Codon: 1
Protein Length: 1754 | Molecular Weight (kDa): 208.59
UniProt ID(s): Q8I2Q1
PDB ID(s): None
Isoelectric Point: 7.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR039762 | Nonsense-mediated mRNA decay protein Nmd2/UPF2 |
| PFam | N/A | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 38198768 | Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosomerecycling factors Tma20/22 in nonsense mediated decay | Pacheco M, D'Orazio KN, ..., Green R | 10.1093/g3journal/jkad295 |