PF3D7_0926100

Genome location: Pf3D7_09_v3:1,047,843..1,059,006(-)

Genome classification: Core

Function and Localization

Product Description: protein kinase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	1.78	0.34
Trophozoite	expressed	1.25	0.41
Schizont	expressed	1.02	0.53
Gametocyte	expressed	1.26	0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0926100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.387 | #Insertions: 8

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0826900)

Relative Growth Rate: 0.29 ± 0.29
Confidence: 3.86

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0826900)

Modification: Disrupted | RMgm-535

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.7.11.1	non-specific serine/threonine protein kinase	ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133087

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	40	126	74	157
disruptive	198	422	214	579
missense	91	303	167	447

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	64	252	124	188
disruptive	306	894	383	871
missense	154	642	290	571

PlasmoDB Total SNPs: 665

Non-coding: 121 | Synonymous: 233 | Nonsynonymous: 310 | Stop Codon: 1

Protein Information

Protein Length: 3178 | Molecular Weight (kDa): 366.96

UniProt ID(s): Q8I2P8

PDB ID(s): None

Isoelectric Point: 6.56

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000719	Protein kinase domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR011009	Protein kinase-like domain superfamily
PFam	PF00069	Protein kinase domain
Superfamily	SSF56112	Protein kinase-like domain superfamily