PF3D7_0926400

Genome location: Pf3D7_09_v3:1,070,433..1,073,592(-)

Genome classification: Core

Function and Localization

Product Description: monocarboxylate transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Component	GO:0016021	integral component of membrane
Component	GO:0016020	membrane
Function	GO:0008028	monocarboxylic acid transmembrane transporter activity
Process	GO:0015718	monocarboxylic acid transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.13	0.93
Trophozoite	expressed	0.60	0.67
Schizont	expressed	0.27	0.83
Gametocyte	expressed	1.66	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0926400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.983 | MFS: -2.835 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H564

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105412

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	21	19	43
disruptive	7	32	23	80
missense	7	31	22	75

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	58	27	44
disruptive	14	95	62	135
missense	10	83	50	104

PlasmoDB Total SNPs: 149

Non-coding: 124 | Synonymous: 17 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 529 | Molecular Weight (kDa): 60.708

UniProt ID(s): C0H564

PDB ID(s): None

Isoelectric Point: 9.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR036259	MFS transporter superfamily
PFam	PF07690	Major facilitator superfamily
Superfamily	SSF103473	MFS transporter superfamily

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895