PF3D7_0926500

Genome location: Pf3D7_09_v3:1,074,538..1,083,991(-)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.31	0.86
Trophozoite	possibly expressed	0.68	0.65
Schizont	expressed	1.04	0.53
Gametocyte	possibly expressed	1.64	0.29

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0926500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.602 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2P4

"Best" AlphaFill ligand hit: 6OU ([(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate, Local RMSD=0.05) with 6BR9 (Global RMSD=23.59)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533543

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	27	86	61	117
disruptive	82	274	133	317
missense	47	197	117	253

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	39	191	76	125
disruptive	162	492	248	513
missense	87	372	189	354

PlasmoDB Total SNPs: 399

Non-coding: 205 | Synonymous: 96 | Nonsynonymous: 94 | Stop Codon: 4

Protein Information

Protein Length: 1922 | Molecular Weight (kDa): 229.941

UniProt ID(s): Q8I2P4

PDB ID(s): None

Isoelectric Point: 7.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
PFam	N/A	N/A
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily