About Gene List

PF3D7_0926600

Genome location: Pf3D7_09_v3:1,084,696..1,089,093(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 12

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.13 0.94
Trophozoite not expressed 0.07 0.96
Schizont not expressed 0.09 0.94
Gametocyte not expressed 0.28 0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0926600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.039 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0827400)

Modification: Disrupted | RMgm-2423

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H565

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533658

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 40 33 80
disruptive 43 125 59 224
missense 31 112 54 193

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 100 48 99
disruptive 86 249 122 262
missense 54 210 110 205

PlasmoDB Total SNPs: 158

Non-coding: 46 | Synonymous: 73 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1378 | Molecular Weight (kDa): 163.175

UniProt ID(s): C0H565

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095