About Gene List

PF3D7_0926800

Genome location: Pf3D7_09_v3:1,092,809..1,096,677(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.71 0.73
Trophozoite not expressed 0.96 0.52
Schizont not expressed 0.57 0.70
Gametocyte expressed 1.39 0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0926800

Resistome Missense Mutations: M436I, C445G, F448L

Resistome Compounds with Missense Mutations: AN13762, AN13956

Resistome # Samples with Disruptive Mutations: 8 (8 missense, 8 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.186 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2P1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533154

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 44 25 53
disruptive 52 149 83 244
missense 30 120 75 216

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 17 81 48 66
disruptive 84 319 138 266
missense 45 265 116 226

PlasmoDB Total SNPs: 131

Non-coding: 15 | Synonymous: 66 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 1225 | Molecular Weight (kDa): 144.99

UniProt ID(s): Q8I2P1

PDB ID(s): None

Isoelectric Point: 8.54

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104