Product Description: replication termination factor, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Process | GO:0071171 | site-specific DNA replication termination at RTS1 barrier |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.25 | 0.88 |
| Trophozoite | expressed | 0.47 | 0.72 |
| Schizont | expressed | 0.32 | 0.78 |
| Gametocyte | expressed | 0.36 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0926900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.758 | MFS: -3.016 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2P0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102106
Most Similar Human Ortholog: A0A0A0MQR2
TM-align score: 0.66 | RMSD: 3.22
Seq Identity: 0.23 | Length: 182 / 225
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000022277 | replication termination factor 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 72
Non-coding: 70 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 225 | Molecular Weight (kDa): 26.1
UniProt ID(s): Q8I2P0
PDB ID(s): None
Isoelectric Point: 10.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006735 | Replication termination factor 2 |
| InterPro | IPR027799 | Replication termination factor 2, RING-finger |
| PFam | PF04641 | Replication termination factor 2, RING-finger |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |