Genome location: Pf3D7_09_v3:1,098,803..1,100,298(+)
Genome classification: Core
Product Description: HSP90 co-chaperone p23
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0032502 | developmental process |
| Process | GO:0032780 | negative regulation of ATP-dependent activity |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.98 |
| Trophozoite | not expressed | 0.18 | 0.88 |
| Schizont | expressed | 0.19 | 0.86 |
| Gametocyte | possibly expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0927000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.154 | MFS: -3.918 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0827800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0827800)
Modification: Disrupted | RMgm-2425
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2N9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105792
Most Similar Human Ortholog: Q8WVJ2
TM-align score: 0.83 | RMSD: 2.23
Seq Identity: 0.25 | Length: 146 / 156
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000170584 | NudC domain containing 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 86
Non-coding: 78 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 156 | Molecular Weight (kDa): 18.369
UniProt ID(s): Q8I2N9
PDB ID(s): None
Isoelectric Point: 5.73
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007052 | CS domain |
| InterPro | IPR008978 | HSP20-like chaperone |
| InterPro | IPR037898 | NudC family |
| PFam | PF04969 | CS domain |
| Superfamily | SSF49764 | HSP20-like chaperone |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 29191421 | Comparative studies of the low-resolution structure of two p23 co-chaperones forHsp90 identified in Plasmodium falciparum genome. | Silva NSM, Seraphim TV, ..., Borges JC | 10.1016/j.ijbiomac.2017.11.161 |