PF3D7_0927100

Genome location: Pf3D7_09_v3:1,099,900..1,101,387(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	expressed	0.30	0.80
Schizont	expressed	0.07	0.95
Gametocyte	expressed	1.25	0.39

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0927100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.261 | MFS: -3.322 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0827900)

Relative Growth Rate: 0.78 ± 0.19
Confidence: 4.68

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0827900)

Modification: Tagged | RMgm-4968

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2N8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139481

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	6	7	5
disruptive	4	12	7	14
missense	4	12	7	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	16	5	20
disruptive	6	28	16	50
missense	5	24	13	37

PlasmoDB Total SNPs: 22

Non-coding: 10 | Synonymous: 11 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 192 | Molecular Weight (kDa): 22.751

UniProt ID(s): Q8I2N8

PDB ID(s): None

Isoelectric Point: 8.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21