About Gene List

PF3D7_0927200

Genome location: Pf3D7_09_v3:1,106,517..1,112,880(+)

Genome classification: Core

Function and Localization

Product Description: gametocyte development protein GD1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.35 0.86
Trophozoite not expressed 0.09 0.95
Schizont expressed 0.14 0.92
Gametocyte expressed 1.16 0.43

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0927200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.894 | MFS: -2.27 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0828000)

Modification: Disrupted | RMgm-5068

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H566

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127249

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 27 89 60 111
disruptive 86 223 139 324
missense 48 174 111 253

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 42 181 78 115
disruptive 138 520 243 561
missense 80 394 182 328

PlasmoDB Total SNPs: 323

Non-coding: 145 | Synonymous: 94 | Nonsynonymous: 84 | Stop Codon: 0

Protein Information

Protein Length: 1627 | Molecular Weight (kDa): 189.7

UniProt ID(s): C0H566

PDB ID(s): None

Isoelectric Point: 5.77

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000571 Zinc finger, CCCH-type
InterPro IPR036855 Zinc finger, CCCH-type superfamily
PFam PF00642 Zinc finger, CCCH-type
Superfamily SSF90229 Zinc finger, CCCH-type superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104