PF3D7_0927500

Genome location: Pf3D7_09_v3:1,119,831..1,122,373(-)

Genome classification: Core

Function and Localization

Product Description: dynein light chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.06	0.95
Gametocyte	possibly expressed	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0927500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.194 | MFS: -3.336 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H568

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=3.74) with 3E70 (Global RMSD=20.07)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101714

Most Similar Human Ortholog: P63172

TM-align score: 0.96 | RMSD: 1.11

Seq Identity: 0.36 | Length: 112 / 112

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000146425	dynein light chain Tctex-type 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	1
missense	0	0	0	0

PlasmoDB Total SNPs: 160

Non-coding: 158 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 112 | Molecular Weight (kDa): 12.963

UniProt ID(s): C0H568

PDB ID(s): None

Isoelectric Point: 4.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005334	Dynein light chain Tctex-1 like
PFam	PF03645	Dynein light chain Tctex-1 like
Superfamily	N/A	N/A