About Gene List

PF3D7_0927600

Genome location: Pf3D7_09_v3:1,122,096..1,125,906(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0071204 histone pre-mRNA 3'end processing complex
Component GO:0005634 nucleus
Function GO:0071207 histone pre-mRNA stem-loop binding
Function GO:0003729 mRNA binding
Process GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage
Process GO:0051028 mRNA transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite expressed 0.81 0.56
Schizont expressed 1.03 0.47
Gametocyte expressed 1.33 0.41

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0927600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.286 | MFS: -2.808 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2N3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103940

Most Similar Human Ortholog: E7EUV9

TM-align score: 0.31 | RMSD: 3.91

Seq Identity: 0.23 | Length: 89 / 595

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000163950 stem-loop binding protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 20 19 31
disruptive 14 83 34 118
missense 11 79 31 96

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 50 25 35
disruptive 38 195 76 194
missense 24 165 53 114

PlasmoDB Total SNPs: 171

Non-coding: 137 | Synonymous: 13 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 595 | Molecular Weight (kDa): 69.552

UniProt ID(s): Q8I2N3

PDB ID(s): None

Isoelectric Point: 9.72

Protein Domain Annotations:

Source Family ID Description
InterPro IPR026502 Histone RNA stem-loop-binding protein SLBP1/SLBP2
InterPro IPR029344 Histone RNA hairpin-binding protein, RNA-binding domain
PFam PF15247 Histone RNA hairpin-binding protein, RNA-binding domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108