Genome location: Pf3D7_09_v3:1,128,345..1,130,169(+)
Genome classification: Core
Product Description: cytochrome c oxidase subunit 5B, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.9.3.1 (Transferred entry: 7.1.1.9)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Process | GO:0042776 | mitochondrial ATP synthesis coupled proton transport |
| Process | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.12 | 0.91 |
| Schizont | expressed | 0.15 | 0.89 |
| Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0927800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.989 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0828600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2N1
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.9.3.1 | cytochrome-c oxidase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 13 | 7 | 19 |
| disruptive | 0 | 3 | 3 | 23 |
| missense | 0 | 3 | 2 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 32 | 15 | 16 |
| disruptive | 2 | 11 | 19 | 64 |
| missense | 1 | 9 | 15 | 47 |
PlasmoDB Total SNPs: 121
Non-coding: 110 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 273 | Molecular Weight (kDa): 32.364
UniProt ID(s): Q8I2N1
PDB ID(s): None
Isoelectric Point: 6.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002124 | Cytochrome c oxidase, subunit Vb |
| PFam | PF01215 | Cytochrome c oxidase, subunit Vb |
| Superfamily | SSF57802 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30204084 | Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase | Seidi A, Muellner-Wong LS, ..., van Dooren GG | 10.7554/eLife.38131 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 35472435 | Regulation of gut microbiota and intestinal metabolites by Poria cocosoligosaccharides improves glycolipid metabolism disturbance in high-fat diet-fedmice | Zhu L, Ye C, ..., Liu H | 10.1016/j.jnutbio.2022.109019 |