Genome location: Pf3D7_09_v3:1,130,507..1,134,907(-)
Genome classification: Core
Product Description: phosphatidylserine decarboxylase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 4.1.1.65 (Phosphatidylserine decarboxylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016020 | membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0004609 | phosphatidylserine decarboxylase activity |
| Process | GO:0006646 | phosphatidylethanolamine biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.21 | 0.86 |
| Schizont | expressed | 0.40 | 0.74 |
| Gametocyte | expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0927900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -2.96 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0828700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9GPP8
"Best" AlphaFill ligand hit: PEE (dope, Local RMSD=0.93) with 6L07 (Global RMSD=6.17)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 4.1.1.65 | phosphatidylserine decarboxylase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102081
Most Similar Human Ortholog: Q9UG56
TM-align score: 0.77 | RMSD: 1.81
Seq Identity: 0.34 | Length: 284 / 353
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000241878 | phosphatidylserine decarboxylase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 342
Non-coding: 323 | Synonymous: 12 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 353 | Molecular Weight (kDa): 41.548
PDB ID(s): None
Isoelectric Point: 9.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003817 | Phosphatidylserine decarboxylase-related |
| InterPro | IPR033177 | Phosphatidylserine decarboxylase |
| InterPro | IPR033661 | Phosphatidylserine decarboxylase, eukaryotic type 1 |
| PFam | PF02666 | Phosphatidylserine decarboxylase-related |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 14651609 | Characterization of a non-mitochondrial type I phosphatidylserine decarboxylasein Plasmodium falciparum. | Baunaure F, Eldin P, Cathiard AM, Vial H | 10.1046/j.1365-2958.2003.03822.x |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |