Genome location: Pf3D7_09_v3:1,134,936..1,136,835(+)
Genome classification: Core
Product Description: cytochrome c oxidase subunit 6B, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.9.3.1 (Transferred entry: 7.1.1.9)
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0928000.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.153 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0828800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2M9
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102345
Most Similar Human Ortholog: P14854
TM-align score: 0.66 | RMSD: 2.15
Seq Identity: 0.29 | Length: 69 / 103
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126267 | cytochrome c oxidase subunit 6B1 |
| ENSG00000160471 | cytochrome c oxidase subunit 6B2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 6 | 1 | 4 |
| disruptive | 1 | 7 | 4 | 13 |
| missense | 1 | 7 | 4 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 7 | 2 | 6 |
| disruptive | 1 | 16 | 10 | 14 |
| missense | 1 | 15 | 9 | 7 |
PlasmoDB Total SNPs: 117
Non-coding: 113 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 103 | Molecular Weight (kDa): 12.225
UniProt ID(s): Q8I2M9
PDB ID(s): None
Isoelectric Point: 6.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003213 | Cytochrome c oxidase, subunit VIb |
| InterPro | IPR036549 | Cytochrome c oxidase, subunit VIb superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF47694 | Cytochrome c oxidase, subunit VIb superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |