PF3D7_0928100

Genome location: Pf3D7_09_v3:1,136,403..1,138,628(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.81	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0928100

Resistome Missense Mutations: K291N

Resistome Compounds with Missense Mutations: MMV668399

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.035 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0828900)

Modification: Disrupted | RMgm-2432

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2M8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533296

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	24	16	22
disruptive	43	63	40	111
missense	23	41	26	64

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	45	19	26
disruptive	57	137	71	147
missense	28	87	47	77

PlasmoDB Total SNPs: 167

Non-coding: 104 | Synonymous: 32 | Nonsynonymous: 30 | Stop Codon: 1

Protein Information

Protein Length: 405 | Molecular Weight (kDa): 49.068

UniProt ID(s): Q8I2M8

PDB ID(s): None

Isoelectric Point: 4.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A