PF3D7_0928200

Genome location: Pf3D7_09_v3:1,139,049..1,142,891(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.19	0.91
Trophozoite	possibly expressed	0.44	0.74
Schizont	possibly expressed	0.10	0.93
Gametocyte	not expressed	0.39	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0928200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 6 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.407 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2M7

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=3.22) with 6QE6 (Global RMSD=18.77)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533761

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	33	21	56
disruptive	32	77	51	143
missense	26	72	46	112

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	74	29	46
disruptive	52	201	94	212
missense	41	154	73	131

PlasmoDB Total SNPs: 268

Non-coding: 191 | Synonymous: 34 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 684 | Molecular Weight (kDa): 83.024

UniProt ID(s): Q8I2M7

PDB ID(s): None

Isoelectric Point: 8.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A