PF3D7_0928300

Genome location: Pf3D7_09_v3:1,142,674..1,144,994(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.05	0.97
Trophozoite	expressed	0.14	0.90
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0928300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.804 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0829100)

Relative Growth Rate: 0.27 ± 0.17
Confidence: 4.90

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0829100)

Modification: Disrupted | RMgm-2433

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H569

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533322

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	12	4	20
disruptive	6	35	18	45
missense	6	34	17	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	21	11	16
disruptive	12	65	36	48
missense	10	58	31	35

PlasmoDB Total SNPs: 179

Non-coding: 159 | Synonymous: 15 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 197 | Molecular Weight (kDa): 23.393

UniProt ID(s): C0H569

PDB ID(s): None

Isoelectric Point: 9.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A