PF3D7_0928400

Genome location: Pf3D7_09_v3:1,145,077..1,146,038(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.00	1.00
Trophozoite	expressed	0.01	1.00
Schizont	expressed	0.00	1.00
Gametocyte	expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0928400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.888 | MFS: -2.148 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0829200)

Relative Growth Rate: 0.13 ± 0.15
Confidence: 5.15

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2M5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_135497

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	8	20
disruptive	6	6	7	13
missense	6	6	6	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	22	14	17
disruptive	9	18	14	45
missense	8	15	10	33

PlasmoDB Total SNPs: 0

Non-coding: 0 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 224 | Molecular Weight (kDa): 25.625

UniProt ID(s): Q8I2M5

PDB ID(s): None

Isoelectric Point: 6.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A