PF3D7_0928500

Genome location: Pf3D7_09_v3:1,145,092..1,147,569(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.23	0.89
Trophozoite	possibly expressed	0.21	0.88
Schizont	possibly expressed	0.04	0.97
Gametocyte	expressed	0.57	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0928500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.151 | MFS: -2.893 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0829300)

Relative Growth Rate: 0.86 ± 0.19
Confidence: 4.70

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0829300)

Modification: Disrupted | RMgm-2435

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2M4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532491

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	5	0	5
disruptive	7	22	17	31
missense	2	16	14	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	7	3	11
disruptive	14	58	24	58
missense	5	35	19	40

PlasmoDB Total SNPs: 178

Non-coding: 167 | Synonymous: 1 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 154 | Molecular Weight (kDa): 18.457

UniProt ID(s): Q8I2M4

PDB ID(s): None

Isoelectric Point: 11.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108