PF3D7_0928600

Genome location: Pf3D7_09_v3:1,147,690..1,149,688(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	not expressed	0.10	0.94
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.03	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0928600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.2 | MFS: -2.909 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0829400)

Relative Growth Rate: 0.65 ± 0.19
Confidence: 4.73

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0829400)

Modification: Disrupted | RMgm-2436

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2M3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533387

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	1	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	5	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 129

Non-coding: 122 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 1

Protein Information

Protein Length: 113 | Molecular Weight (kDa): 13.255

UniProt ID(s): Q8I2M3

PDB ID(s): None

Isoelectric Point: 8.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A