PF3D7_0928700

Genome location: Pf3D7_09_v3:1,149,710..1,155,532(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	possibly expressed	0.47	0.73
Schizont	not expressed	0.13	0.92
Gametocyte	not expressed	0.48	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0928700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.029 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2M2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_117036

Most Similar Human Ortholog: Q5HY64

TM-align score: 0.27 | RMSD: 8.00

Seq Identity: 0.05 | Length: 406 / 1501

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000198173	family with sequence similarity 47 member C

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	73	32	83
disruptive	65	252	125	252
missense	36	185	112	224

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	127	48	94
disruptive	136	461	192	390
missense	66	362	171	279

PlasmoDB Total SNPs: 280

Non-coding: 103 | Synonymous: 93 | Nonsynonymous: 84 | Stop Codon: 0

Protein Information

Protein Length: 1501 | Molecular Weight (kDa): 181.363

UniProt ID(s): Q8I2M2

PDB ID(s): None

Isoelectric Point: 8.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A