PF3D7_0929000 (TAF7)

Genome location: Pf3D7_09_v3:1,160,773..1,162,919(+)

Genome classification: Core

Function and Localization

Product Description: transcription initiation factor TFIID subunit 7, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005669	transcription factor TFIID complex
Process	GO:0051123	RNA polymerase II preinitiation complex assembly
Process	GO:0006366	transcription by RNA polymerase II

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.18	0.91
Trophozoite	expressed	0.25	0.84
Schizont	possibly expressed	0.06	0.95
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0929000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.198 | MFS: -2.803 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2M0

"Best" AlphaFill ligand hit: AKG (2-oxoglutaric acid, Local RMSD=0.56) with 2QFX (Global RMSD=21.95)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102177

Most Similar Human Ortholog: A0A096LPC3

TM-align score: 0.59 | RMSD: 1.99

Seq Identity: 0.12 | Length: 41 / 397

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000178913	TATA-box binding protein associated factor 7

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	30	11	27
disruptive	5	21	14	39
missense	3	19	14	32

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	45	16	24
disruptive	11	54	34	112
missense	8	42	26	76

PlasmoDB Total SNPs: 117

Non-coding: 97 | Synonymous: 12 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 397 | Molecular Weight (kDa): 46.799

UniProt ID(s): Q8I2M0

PDB ID(s): None

Isoelectric Point: 5.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006751	TAFII55 protein, conserved region
InterPro	IPR037817	Transcription initiation factor TFIID subunit 7
PFam	PF04658	TAFII55 protein, conserved region
Superfamily	N/A	N/A