PF3D7_0929300

Genome location: Pf3D7_09_v3:1,171,132..1,173,562(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.27	0.87
Trophozoite	expressed	0.74	0.61
Schizont	expressed	0.24	0.85
Gametocyte	expressed	0.90	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0929300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.734 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2L7

"Best" AlphaFill ligand hit: PE0 (pterine, Local RMSD=0.07) with 5Z79 (Global RMSD=14.95)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533293

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	33	15	29
disruptive	23	98	45	129
missense	18	81	41	111

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	54	25	50
disruptive	54	221	92	195
missense	35	173	79	135

PlasmoDB Total SNPs: 116

Non-coding: 46 | Synonymous: 37 | Nonsynonymous: 32 | Stop Codon: 1

Protein Information

Protein Length: 714 | Molecular Weight (kDa): 86.575

UniProt ID(s): Q8I2L7

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A