PF3D7_0929500

Genome location: Pf3D7_09_v3:1,180,983..1,181,996(-)

Genome classification: Core

Function and Localization

Product Description: CH domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005930	axoneme
Function	GO:0008017	microtubule binding
Process	GO:0051493	regulation of cytoskeleton organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0929500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.126 | MFS: -3.606 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H572

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103412

Most Similar Human Ortholog: Q9Y4P9

TM-align score: 0.58 | RMSD: 1.94

Seq Identity: 0.40 | Length: 131 / 209

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000101222	sperm flagellar 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	6	1	10
disruptive	4	12	4	6
missense	4	10	4	4

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	10	2	10
disruptive	7	20	4	20
missense	6	13	4	14

PlasmoDB Total SNPs: 20

Non-coding: 16 | Synonymous: 1 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 209 | Molecular Weight (kDa): 24.828

UniProt ID(s): C0H572

PDB ID(s): None

Isoelectric Point: 7.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010441	CH-like domain in sperm protein
InterPro	IPR036872	CH domain superfamily
PFam	PF06294	CH-like domain in sperm protein
Superfamily	SSF47576	CH domain superfamily