PF3D7_0929600

Genome location: Pf3D7_09_v3:1,182,575..1,184,144(-)

Genome classification: Core

Function and Localization

Product Description: G2 protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020039	pellicle

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	possibly expressed	0.31	0.80
Gametocyte	expressed	0.47	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0929600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.899 | MFS: -2.415 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0830400)

Relative Growth Rate: 1.01 ± 0.15
Confidence: 5.20

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0830400)

Modification: Disrupted | RMgm-2440

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2L4

"Best" AlphaFill ligand hit: GSP (5'-guanosine-diphosphate-monothiophosphate, Local RMSD=45.16) with 2XTZ (Global RMSD=47.62)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134706

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	11	5	19
disruptive	1	4	5	12
missense	1	4	5	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	17	14	13
disruptive	5	11	12	25
missense	4	8	12	24

PlasmoDB Total SNPs: 76

Non-coding: 60 | Synonymous: 12 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 272 | Molecular Weight (kDa): 31.989

UniProt ID(s): Q8I2L4

PDB ID(s): None

Isoelectric Point: 6.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23773015	Morphogenesis of Plasmodium zoites is uncoupled from tensile strength.	Tremp AZ, Carter V, Saeed S, Dessens JT	10.1111/mmi.12297