PF3D7_0929700

Genome location: Pf3D7_09_v3:1,184,754..1,186,269(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.20	0.87
Schizont	expressed	0.08	0.95
Gametocyte	not expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0929700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.997 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXG1

"Best" AlphaFill ligand hit: J01 (clavulanic acid, Local RMSD=2.37) with 6NVU (Global RMSD=15.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109076

Most Similar Human Ortholog: C9K0F7

TM-align score: 0.71 | RMSD: 3.48

Seq Identity: 0.11 | Length: 154 / 350

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000205758	crystallin zeta like 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	16	7	9
disruptive	7	29	20	46
missense	7	29	20	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	22	12	12
disruptive	8	71	29	52
missense	8	66	25	43

PlasmoDB Total SNPs: 43

Non-coding: 20 | Synonymous: 16 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 350 | Molecular Weight (kDa): 41.171

UniProt ID(s): A0A143ZXG1

PDB ID(s): None

Isoelectric Point: 6.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A