PF3D7_0929900

Genome location: Pf3D7_09_v3:1,187,369..1,189,282(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.09	0.93
Schizont	no data	0.04	0.97
Gametocyte	no data	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0929900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.515 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0830600)

Relative Growth Rate: 0.24 ± 0.22
Confidence: 4.44

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H574

"Best" AlphaFill ligand hit: DTD (dithiane diol, Local RMSD=13.07) with 6HDR (Global RMSD=20.81)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533429

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	1	18
disruptive	1	22	9	17
missense	1	22	9	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	17	8	13
disruptive	4	33	15	20
missense	4	31	14	13

PlasmoDB Total SNPs: 83

Non-coding: 75 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 191 | Molecular Weight (kDa): 23.077

UniProt ID(s): C0H574

PDB ID(s): None

Isoelectric Point: 10.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895