PF3D7_0930000

Genome location: Pf3D7_09_v3:1,189,646..1,191,322(+)

Genome classification: Core

Function and Localization

Product Description: procollagen lysine 5-dioxygenase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: 1.14.11.4 (Procollagen-lysine 5-dioxygenase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.72	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0930000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.951 | MFS: -2.501 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2L2

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=1.24) with 6FXR (Global RMSD=2.19)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
1.14.11.4	procollagen-lysine 5-dioxygenase	CO2SC65catecholdopaminetyrosinemalaoxonsuccinatemalathionminoxidildipyridylephedrinepyrogallol...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_166646

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	19	9	28
disruptive	8	44	32	40
missense	7	37	28	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	33	16	40
disruptive	17	81	42	73
missense	12	65	35	59

PlasmoDB Total SNPs: 35

Non-coding: 0 | Synonymous: 21 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 558 | Molecular Weight (kDa): 66.843

UniProt ID(s): Q8I2L2

PDB ID(s): None

Isoelectric Point: 8.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A