About Gene List

PF3D7_0930100

Genome location: Pf3D7_09_v3:1,191,714..1,195,486(-)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.16 0.92
Trophozoite expressed 0.82 0.56
Schizont expressed 0.72 0.59
Gametocyte possibly expressed 0.44 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0930100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.144 | MFS: -3.218 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H575

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.81) with 6JWW (Global RMSD=32.22)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533545

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 29 22 51
disruptive 32 105 66 129
missense 17 80 57 107

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 62 46 62
disruptive 59 207 76 175
missense 28 158 64 124

PlasmoDB Total SNPs: 149

Non-coding: 32 | Synonymous: 72 | Nonsynonymous: 44 | Stop Codon: 1

Protein Information

Protein Length: 1150 | Molecular Weight (kDa): 138.632

UniProt ID(s): C0H575

PDB ID(s): None

Isoelectric Point: 8.38

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895