PF3D7_0930200 (LRR8)

Genome location: Pf3D7_09_v3:1,195,511..1,200,623(-)

Genome classification: Core

Function and Localization

Product Description: leucine-rich repeat protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	expressed	0.07	0.96
Schizont	expressed	0.74	0.62
Gametocyte	possibly expressed	0.86	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0930200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.332 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H576

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104691

Most Similar Human Ortholog: J3QRH8

TM-align score: 0.83 | RMSD: 1.33

Seq Identity: 0.37 | Length: 123 / 639

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000171962	dynein regulatory complex subunit 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	singleton
synonymous	0	0
disruptive	1	1
missense	0	0

Any inclusion in genotype call

variant type	common	rare
synonymous	0	0
disruptive	1	1
missense	0	0

PlasmoDB Total SNPs: 331

Non-coding: 298 | Synonymous: 18 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 639 | Molecular Weight (kDa): 76.374

UniProt ID(s): C0H576, Q1L6A1

PDB ID(s): None

Isoelectric Point: 5.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	PF14580	N/A
Superfamily	SSF52075	N/A