Genome location: Pf3D7_09_v3:1,201,305..1,207,576(+)
Genome classification: Core
Product Description: merozoite surface protein 1
SignalP Peptide: MKIIFFLCSFLFFIINTQC
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0046658 | anchored component of plasma membrane |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0046812 | host cell surface binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0044877 | protein-containing complex binding |
| Process | GO:0044409 | entry into host |
| Process | GO:0035891 | exit from host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.11 | 0.65 |
| Trophozoite | expressed | 1.71 | 0.41 |
| Schizont | expressed | 5.08 | 0.00 |
| Gametocyte | expressed | 0.44 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0930300
Resistome Missense Mutations: T465S, E894K
Resistome Compounds with Missense Mutations: Lopinavir, MMV000570
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.141 | MFS: -3.197 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0831000)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0831000)
Modification: Mutated | RMgm-4745
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I0U8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 56 | 25 | 66 |
| disruptive | 193 | 144 | 65 | 162 |
| missense | 150 | 94 | 56 | 115 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 107 | 51 | 78 |
| disruptive | 226 | 234 | 106 | 282 |
| missense | 161 | 158 | 80 | 176 |
PlasmoDB Total SNPs: 495
Non-coding: 96 | Synonymous: 87 | Nonsynonymous: 312 | Stop Codon: 0
Protein Length: 1720 | Molecular Weight (kDa): 195.726
UniProt ID(s): A5A7B4, M1UZN7, M1UZP7, M1UZQ3, M1UZX1, M1VF09, M1VKH7, M1VKQ7, M1VNZ6, Q25922, Q8I0U8
Isoelectric Point: 6.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010901 | Merozoite surface 1, C-terminal |
| InterPro | IPR024730 | Merozoite surface protein, EGF domain 1 |
| PFam | PF07462 | Merozoite surface 1, C-terminal |
| PFam | PF12946 | Merozoite surface protein, EGF domain 1 |
| Superfamily | SSF57196 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 8992312 | Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of themerozoite surface proteins-1 and -2 of Plasmodium falciparum. | Gerold P, Schofield L, ..., Schwarz RT | 10.1016/0166-6851(95)02518-9 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16289042 | Two Plasmodium falciparum merozoite proteins binding to erythrocyte band 3 form adirect complex. | Kariuki MM, Li X, ..., Oh SS | https://pubmed.ncbi.nlm.nih.gov/16289042/ |
| 16940297 | Interactions between merozoite surface proteins 1, 6, and 7 of the malariaparasite Plasmodium falciparum. | Kauth CW, Woehlbier U, ..., Bujard H | 10.1074/jbc.M604641200 |
| 17068840 | Synthesis, solution structure and immune recognition of an epidermal growthfactor-like domain from Plasmodium falciparum merozoite surface protein-1. | James S, Moehle K, ..., Robinson JA | 10.1002/cbic.200600357 |
| 17347029 | Allelic diversity in the merozoite surface protein 1 gene of Plasmodiumfalciparum on Palawan Island, the Philippines. | Sakihama N, Nakamura M, ..., Tanabe K | 10.1016/j.parint.2007.01.011 |
| 17355170 | Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing sitein Mali. | Takala SL, Coulibaly D, ..., Plowe CV | 10.1371/journal.pmed.0040093 |
| 17659072 | Polymorphism and epitope sharing between the alleles of merozoite surfaceprotein-1 of Plasmodium falciparum among Indian isolates. | Mamillapalli A, Sunil S, ..., Malhotra P | 10.1186/1475-2875-6-95 |
| 18292564 | Fine specificity of neonatal lymphocytes to an abundant malaria blood-stageantigen: epitope mapping of Plasmodium falciparum MSP1(33). | Malhotra I, Wamachi AN, ..., King CL | 10.4049/jimmunol.180.5.3383 |
| 18333885 | MSP1(19) miniproteins can serve as targets for invasion inhibitory antibodies inPlasmodium falciparum provided they contain the correct domains for cell surfacetrafficking. | Gilson PR, O'Donnell RA, ..., Crabb BS | 10.1111/j.1365-2958.2008.06140.x |
| 18577328 | Association of msp-1, msp-2 and pfcrt genes with the severe complications ofPlasmodium falciparum malaria in children. | Sahu PK, Pati SS, Satpathy R | 10.1179/136485908X300814 |
| 19069502 | A preliminary study of genetic diversity of MSP-1 types in Plasmodium falciparumin southern province of Sistan Baluchistan of Iran. | Zahra Z, Reza RM, ..., Mohammad R | 10.3923/pjbs.2007.368.372 |
| 19326702 | Genetic diversity in Plasmodium falciparum merozoite surface protein 1 and 2coding genes and its implications in malaria epidemiology: a review of publishedstudies from 1997-2007. | Kiwanuka GN | https://pubmed.ncbi.nlm.nih.gov/19326702/ |
| 19933832 | Plasmodium falciparum merozoite surface protein 1 (MSP-1)-MSP-3 chimeric protein:immunogenicity determined with human-compatible adjuvants and induction ofprotective immune response. | Mazumdar S, Mukherjee P, ..., Chauhan VS | 10.1128/IAI.00427-09 |
| 20070906 | Shift in epitope dominance of IgM and IgG responses to Plasmodium falciparum MSP1block 4. | Chang SP, Kayatani AK, ..., Taylor DW | 10.1186/1475-2875-9-14 |
| 20478015 | Genetic polymorphism of merozoite surface protein-1 and merozoite surfaceprotein-2 in Plasmodium falciparum field isolates from Myanmar. | Kang JM, Moon SU, ..., Na BK | 10.1186/1475-2875-9-131 |
| 20735778 | Regulated maturation of malaria merozoite surface protein-1 is essential forparasite growth. | Child MA, Epp C, Bujard H, Blackman MJ | 10.1111/j.1365-2958.2010.07324.x |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 21175202 | Proteome analysis reveals a large merozoite surface protein-1 associated complexon the Plasmodium falciparum merozoite surface. | Ranjan R, Chugh M, ..., Malhotra P | 10.1021/pr100875y |
| 21278348 | Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired Tcell responses to Plasmodium falciparum antigens. | Mackroth MS, Malhotra I, ..., King CL | 10.4049/jimmunol.1001188 |
| 22177111 | Genetic analysis of the merozoite surface protein-1 block 2 allelic types inPlasmodium falciparum clinical isolates from Lao PDR. | Khaminsou N, Kritpetcharat O, ..., Kritpetcharat P | 10.1186/1475-2875-10-371 |
| 22325817 | Genetic diversity in merozoite surface protein-1 and 2 among Plasmodiumfalciparum isolates from malarious districts of tribal dominant state ofJharkhand, India. | Hussain MM, Sohail M, ..., Raziuddin M | 10.1179/2047773211Y.0000000012 |
| 22431641 | Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatoryprotein S100P. | Waisberg M, Cerqueira GC, ..., Pierce SK | 10.1073/pnas.1202689109 |
| 22439658 | Genetic diversity in the block 2 region of the merozoite surface protein-1 ofPlasmodium falciparum in central India. | Bharti PK, Shukla MM, Sharma YD, Singh N | 10.1186/1475-2875-11-78 |
| 23451153 | New insights for native production of MSP1(19), the disulfide-rich C-terminalfragment from Plasmodium falciparum merozoite surface protein 1. | Planson AG, Guijarro JI, Chaffotte AF | 10.1371/journal.pone.0057086 |
| 23682431 | C-terminal polymorphism of Plasmodium falciparium merozoite surface protein-1(MSP-1) from Tak Province, Thailand. | Viputtigul K, Tungpukdee N, ..., Krudsood S | https://pubmed.ncbi.nlm.nih.gov/23682431/ |
| 24303947 | Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1immunization and controlled malaria infection. | Elias SC, Choudhary P, ..., Draper SJ | 10.1111/imm.12226 |
| 24321092 | Seasonal changes in the antibody responses against Plasmodium falciparummerozoite surface antigens in areas of differing malaria endemicity in Indonesia. | Supargiyono S, Bretscher MT, ..., Drakeley CJ | 10.1186/1475-2875-12-444 |
| 24456636 | Polymorphism of the merozoite surface protein-1 block 2 region in Plasmodiumfalciparum isolates from Mauritania. | Ahmedou Salem MS, Ndiaye M, ..., Mohamed Salem O Boukhary AO | 10.1186/1475-2875-13-26 |
| 25157665 | Human erythrocyte band 3 functions as a receptor for the sialic acid-independentinvasion of Plasmodium falciparum. Role of the RhopH3-MSP1 complex. | Baldwin M, Yamodo I, ..., Chishti AH | 10.1016/j.bbamcr.2014.08.008 |
| 25604491 | alpha-Thalassaemia trait is associated with antibody prevalence against malariaantigens AMA-1 and MSP-1. | Daou M, Kituma E, ..., Doumbo O | 10.1093/tropej/fmu077 |
| 25778531 | Merozoite surface protein 1 recognition of host glycophorin A mediates malariaparasite invasion of red blood cells. | Baldwin MR, Li X, ..., Chishti AH | 10.1182/blood-2014-11-611707 |
| 25786326 | Genetic polymorphism of merozoite surface protein-1 in Plasmodium falciparumisolates from patients with mild to severe malaria in Libreville, Gabon. | Bouyou-Akotet MK, M'Bondoukwe NP, Mawili-Mboumba DP | 10.1051/parasite/2015012 |
| 26468747 | Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates aSpectrin-Binding Function Enabling Parasite Egress from RBCs. | Das S, Hertrich N, ..., Blackman MJ | 10.1016/j.chom.2015.09.007 |
| 26823464 | Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes MediateMerozoite Binding to Human Erythrocytes. | Lin CS, Uboldi AD, ..., Cowman AF | 10.1074/jbc.M115.698282 |
| 28719950 | Isolation and Characterization of Vaccine Candidate Genes Including CSP and MSP1in Plasmodium yoelii. | Kim SH, Bae YA, Seoh JY, Yang HJ | 10.3347/kjp.2017.55.3.255 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 29029367 | Genetic diversity of Plasmodium falciparum merozoite surface protein-1 (block 2),glutamate-rich protein and sexual stage antigen Pfs25 from Chandigarh, NorthIndia. | Kaur H, Sehgal R, ..., Kanwar JR | 10.1111/tmi.12990 |
| 29138437 | Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the innermembrane complex and is required for Plasmodium parasite development. | Saini E, Zeeshan M, ..., Tewari R | 10.1038/s41598-017-15781-z |
| 29355145 | Molecular characterization of Plasmodium falciparum in Arunachal Pradesh fromNortheast India based on merozoite surface protein 1 & glutamate-rich protein. | Sarmah NP, Sarma K, ..., Mahanta J | 10.4103/ijmr.IJMR_291_16 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 32127816 | Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes andmultiplicity of Plasmodium falciparum infection across various endemic areas inSenegal. | Ndiaye T, Sy M, Gaye A, Ndiaye D | 10.4314/ahs.v19i3.19 |
| 33145997 | Prefoldin subunit 6 of Plasmodium falciparum binds merozoite surface protein-1. | Kumar V, Shoaib R, ..., Singh S | 10.1002/2211-5463.13022 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34087264 | Diversity and natural selection of Merozoite surface Protein-1 in three speciesof human malaria parasites: Contribution from South-East Asian isolates. | Goh XT, Lim YAL, ..., Chua KH | 10.1016/j.molbiopara.2021.111390 |
| 34579727 | Detection of high frequency of MAD20 allelic variants of Plasmodium falciparummerozoite surface protein 1 gene from Adama and its surroundings, Oromia,Ethiopia. | File T, Chekol T, ..., Golassa L | 10.1186/s12936-021-03914-9 |
| 34993632 | Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated fromsymptomatic and asymptomatic malaria subjects in the South of Benin. | Lagnika HO, Moussiliou A, ..., Djogbenou LS | 10.1007/s00436-021-07399-y |
| 36522733 | Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2and multiplicity of infections in western Ethiopia following effective malariainterventions. | Tadele G, Jaiteh FK, ..., Golassa L | 10.1186/s12936-022-04394-1 |
| 38111629 | Merozoite surface protein 1 paralog is involved in the human erythrocyte invasionof a zoonotic malaria, Plasmodium knowlesi | Lee SK, Nguyen TK, ..., Han ET | 10.3389/fcimb.2023.1314533 |
| 37751696 | A genomic platform for surveillance and antigen discovery in Plasmodium spp.using long-read amplicon sequencing | Plaza DF, Zerebinski J, ..., Farnert A | 10.1016/j.crmeth.2023.100574 |
| 38281044 | msp1, msp2, and glurp genotyping to differentiate Plasmodium falciparumrecrudescence from reinfections during prevention of reestablishment phase, SriLanka, 2014-2019 | Gunasekera KT, Premaratne RG, ..., Fernando DS | 10.1186/s12936-024-04858-6 |
| 38400191 | IgG Subclass Switch in Volunteers Repeatedly Immunized with the Full-LengthPlasmodium falciparum Merozoite Surface Protein 1 (MSP1) | Rathay V, Furle K, ..., Thomson-Luque R | 10.3390/vaccines12020208 |
| 37723449 | Tracking the geographical origin of Plasmodium falciparum causing a rare severecase of malaria imported into Palestine, a zero-indigenous case area | Al-Jawabreh A, Ereqat S, ..., Nasereddin A | 10.1186/s12879-023-08583-4 |
| 37754682 | Associations between prenatal malaria exposure, maternal antibodies at birth, andmalaria susceptibility during the first year of life in Burkina Faso | Natama HM, Moncunill G, ..., Dobano C | 10.1128/iai.00268-23 |
| 37693871 | Analytical approaches for antimalarial antibody responses to confirm historicaland recent malaria transmission: an example from the Philippines | Macalinao MLM, Fornace KM, ..., Drakeley CJ | 10.1016/j.lanwpc.2023.100792 |
| 37897161 | Multiplicity of infection of Plasmodium knowlesi in Malaysia: an application ofPkmsp-1 block IV | Noordin NR, Azhar A, ..., Fong MY | 10.47665/tb.40.3.004 |
| 37978446 | Genetic diversity of merozoite surface protein-5 (MSP-5) of Plasmodium vivaxisolates from Malaria patients in Iran | Mansouri S, Heidari A, ..., Mahmoudi E | 10.1186/s12879-023-08804-w |
| 38392910 | A Comparative Study of Genetic Diversity and Multiplicity of Infection inUncomplicated Plasmodium falciparum Infections in Selected Regions ofPre-Elimination and High Transmission Settings Using MSP1 and MSP2 Genes | Akoniyon OP, Akiibinu M, ..., Okpeku M | 10.3390/pathogens13020172 |
| 38100310 | Plasmodium falciparum merozoite surface protein 1 as asexual blood stage malariavaccine candidate | Thomson-Luque R, Stabler TC, ..., Daubenberger C | 10.1080/14760584.2023.2295430 |
| 38043541 | Genetic polymorphism of merozoite surface protein 1 and antifolate-resistantgenes in Plasmodium falciparum from Mali and Niger | Lamine MM, Maman R, Maiga AA, Laminou IM | 10.3347/PHD.23049 |
| 38254075 | Geospatial analysis of Plasmodium falciparum serological indicators: schoolversus community sampling in a low-transmission malaria setting | Jaramillo-Underwood A, Herman C, ..., Rogier E | 10.1186/s12916-023-03145-6 |
| 37849789 | Plasmodium falciparum Genetic Diversity and Resistance Genotype Profile inInfected Placental Samples Collected After Delivery in Ouagadougou | Sawadogo H, Soulama I, ..., Savadogo A | 10.2147/IDR.S420004 |