PF3D7_0930400

Genome location: Pf3D7_09_v3:1,207,579..1,212,987(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0061630	ubiquitin protein ligase activity
Process	GO:0016567	protein ubiquitination
Process	GO:0006511	ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0930400.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.243 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0831100)

Relative Growth Rate: 1.01 ± 0.16
Confidence: 5.09

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0831100)

Modification: Disrupted | RMgm-2443

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2L0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105273

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	39	15	52
disruptive	34	126	58	126
missense	17	95	45	96

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	73	43	40
disruptive	79	260	113	301
missense	39	176	78	186

PlasmoDB Total SNPs: 265

Non-coding: 157 | Synonymous: 84 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 915 | Molecular Weight (kDa): 107.401

UniProt ID(s): Q8I2L0

PDB ID(s): None

Isoelectric Point: 9.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001005	SANT/Myb domain
InterPro	IPR009057	Homeobox-like domain superfamily
InterPro	IPR037274	Zinc finger, CHY-type superfamily
PFam	PF00249	SANT/Myb domain
Superfamily	SSF161219	Zinc finger, CHY-type superfamily
Superfamily	SSF46689	Homeobox-like domain superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104