Genome location: Pf3D7_09_v3:1,217,433..1,221,199(-)
Genome classification: Core
Product Description: peptidyl-prolyl cis-trans isomerase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0930600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.897 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2K8
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.2.1.8 | peptidylprolyl isomerase | ATPNEMSDSPCMBFK506QAEGPKAla-ProjugloneSer-ProGPI-1046RNase T1Rapamycin... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102815
Most Similar Human Ortholog: A0A7P0T8P6
TM-align score: 0.58 | RMSD: 3.25
Seq Identity: 0.18 | Length: 83 / 609
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100023 | peptidylprolyl isomerase like 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 24 | 14 | 37 |
| disruptive | 15 | 67 | 42 | 73 |
| missense | 14 | 60 | 39 | 61 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 49 | 21 | 38 |
| disruptive | 37 | 166 | 71 | 143 |
| missense | 23 | 127 | 56 | 90 |
PlasmoDB Total SNPs: 150
Non-coding: 109 | Synonymous: 18 | Nonsynonymous: 23 | Stop Codon: 0
Protein Length: 609 | Molecular Weight (kDa): 72.552
UniProt ID(s): Q8I2K8
PDB ID(s): None
Isoelectric Point: 9.48
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| InterPro | IPR029000 | Cyclophilin-like domain superfamily |
| PFam | PF00160 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| Superfamily | SSF50891 | Cyclophilin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30474973 | A Combinatorial Approach To Study Cytochrome P450 Enzymes for De Novo Productionof Steviol Glucosides in Baker's Yeast | Gold ND, Fossati E, ..., Martin VJJ | 10.1021/acssynbio.8b00470 |