PF3D7_0930700

Genome location: Pf3D7_09_v3:1,221,470..1,224,028(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.37	0.82
Trophozoite	possibly expressed	0.55	0.69
Schizont	not expressed	0.07	0.96
Gametocyte	not expressed	0.49	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0930700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.484 | MFS: -2.521 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2K7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532660

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	23	17	28
disruptive	5	38	23	50
missense	3	36	22	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	48	17	31
disruptive	11	96	41	114
missense	6	78	33	73

PlasmoDB Total SNPs: 131

Non-coding: 101 | Synonymous: 23 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 463 | Molecular Weight (kDa): 56.2

UniProt ID(s): Q8I2K7

PDB ID(s): None

Isoelectric Point: 9.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A