About Gene List

PF3D7_0931200 (SEL2)

Genome location: Pf3D7_09_v3:1,258,494..1,259,859(+)

Genome classification: Core

Function and Localization

Product Description: selenoprotein 2

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005783 endoplasmic reticulum
Process GO:0045454 cell redox homeostasis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.02 0.99
Trophozoite expressed 0.04 0.97
Schizont possibly expressed 0.01 1.00
Gametocyte expressed 0.05 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0931200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.781 | MFS: -2.617 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0832000)

  • Relative Growth Rate: 0.97 ± 0.11
  • Confidence: 5.82

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0832000)

Modification: Disrupted | RMgm-2447

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533739

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 16 10 12
disruptive 0 17 7 28
missense 0 16 7 24

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 31 6 14
disruptive 6 52 33 82
missense 2 40 24 44

PlasmoDB Total SNPs: 89

Non-coding: 65 | Synonymous: 17 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 229 | Molecular Weight (kDa): 27.67

UniProt ID(s): C0Z3M5

PDB ID(s): None

Isoelectric Point: 9.59

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
22229886 Insight into the selenoproteome of the malaria parasite Plasmodium falciparum. Roseler A, Prieto JH, ..., Becker K 10.1089/ars.2011.4276