PF3D7_0931300

Genome location: Pf3D7_09_v3:1,260,984..1,261,969(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.02	0.99
Gametocyte	possibly expressed	0.15	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0931300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.679 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2K2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533242

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	10	3	17
disruptive	21	26	25	39
missense	18	23	24	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	24	8	17
disruptive	27	83	35	72
missense	20	67	28	52

PlasmoDB Total SNPs: 32

Non-coding: 2 | Synonymous: 15 | Nonsynonymous: 14 | Stop Codon: 1

Protein Information

Protein Length: 305 | Molecular Weight (kDa): 35.529

UniProt ID(s): Q8I2K2

PDB ID(s): None

Isoelectric Point: 4.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A