PF3D7_0931400

Genome location: Pf3D7_09_v3:1,262,730..1,265,679(+)

Genome classification: Core

Function and Localization

Product Description: PUB domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.37	0.83
Trophozoite	expressed	1.07	0.46
Schizont	expressed	0.47	0.72
Gametocyte	expressed	0.66	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0931400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.272 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H579

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.37) with 3WQT (Global RMSD=6.95)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111405

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 113

Non-coding: 100 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 310 | Molecular Weight (kDa): 37.161

UniProt ID(s): C0H579

PDB ID(s): None

Isoelectric Point: 6.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009060	UBA-like superfamily
InterPro	IPR018997	PUB domain
InterPro	IPR036339	PUB-like domain superfamily
PFam	PF09409	PUB domain
Superfamily	SSF143503	PUB-like domain superfamily
Superfamily	SSF46934	UBA-like superfamily