PF3D7_0931600

Genome location: Pf3D7_09_v3:1,268,277..1,269,415(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0931600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -2.973 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0832400)

Relative Growth Rate: 0.96 ± 0.26
Confidence: 4.06

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0832400)

Modification: Disrupted | RMgm-2449

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2J9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104602

Most Similar Human Ortholog: A0A087WX50

TM-align score: 0.67 | RMSD: 2.17

Seq Identity: 0.23 | Length: 68 / 251

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000197826	cilia and flagella associated protein 299

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	6	5	20
disruptive	5	21	13	27
missense	5	21	13	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	29	6	14
disruptive	15	56	29	63
missense	9	43	19	36

PlasmoDB Total SNPs: 54

Non-coding: 43 | Synonymous: 5 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 251 | Molecular Weight (kDa): 30.308

UniProt ID(s): Q8I2J9

PDB ID(s): None

Isoelectric Point: 8.94

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027887	Protein of unknown function DUF4464
PFam	PF14713	Protein of unknown function DUF4464
Superfamily	N/A	N/A