PF3D7_0931700

Genome location: Pf3D7_09_v3:1,270,155..1,272,656(+)

Genome classification: Core

Function and Localization

Product Description: PIH1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.01	0.99
Trophozoite	not expressed	0.06	0.97
Schizont	possibly expressed	0.05	0.97
Gametocyte	possibly expressed	0.37	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0931700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.358 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0832500)

Relative Growth Rate: 1.00 ± 0.13
Confidence: 5.40

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0832500)

Modification: Disrupted | RMgm-2450

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H581

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105060

Most Similar Human Ortholog: Q9NVR5

TM-align score: 0.27 | RMSD: 7.37

Seq Identity: 0.07 | Length: 274 / 715

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000165506	dynein axonemal assembly factor 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	30	16	43
disruptive	19	81	43	105
missense	10	73	36	95

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	57	34	35
disruptive	33	175	64	170
missense	21	147	54	133

PlasmoDB Total SNPs: 141

Non-coding: 57 | Synonymous: 42 | Nonsynonymous: 39 | Stop Codon: 3

Protein Information

Protein Length: 715 | Molecular Weight (kDa): 85.234

UniProt ID(s): C0H581

PDB ID(s): None

Isoelectric Point: 5.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012981	PIH1, N-terminal
PFam	PF08190	PIH1, N-terminal
Superfamily	N/A	N/A