About Gene List

PF3D7_0931900 (AKLP2)

Genome location: Pf3D7_09_v3:1,274,656..1,277,085(-)

Genome classification: Core

Function and Localization

Product Description: adenylate kinase-like protein 2

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.7.4.3 (Adenylate kinase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.01 0.99
Trophozoite possibly expressed 0.02 0.99
Schizont expressed 0.26 0.84
Gametocyte expressed 0.47 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0931900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.151 | MFS: -3.467 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H582

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=3.57) with 3TLX (Global RMSD=4.15)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
2.7.4.3 adenylate kinase BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532879

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 15 5 14
disruptive 2 19 6 24
missense 2 18 6 21

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 25 8 17
disruptive 5 44 19 56
missense 3 35 17 44

PlasmoDB Total SNPs: 158

Non-coding: 141 | Synonymous: 14 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 263 | Molecular Weight (kDa): 31.095

UniProt ID(s): C0H582

PDB ID(s): None

Isoelectric Point: 6.31

Protein Domain Annotations:

Source Family ID Description
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFam N/A N/A
Superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolase

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
22819813 Subcellular localization of adenylate kinases in Plasmodium falciparum. Ma J, Rahlfs S, ..., Becker K 10.1016/j.febslet.2012.07.013