PF3D7_0932000

Genome location: Pf3D7_09_v3:1,277,432..1,279,277(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	possibly expressed	0.07	0.96
Schizont	expressed	0.61	0.70
Gametocyte	possibly expressed	0.64	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0932000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.975 | MFS: -2.103 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0832800)

Relative Growth Rate: 0.99 ± 0.18
Confidence: 4.83

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0832800)

Modification: Disrupted | RMgm-2452

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H583

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532711

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 118

Non-coding: 112 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 102 | Molecular Weight (kDa): 10.994

UniProt ID(s): C0H583

PDB ID(s): None

Isoelectric Point: 4.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A