Genome location: Pf3D7_09_v3:1,297,285..1,298,239(-)
Genome classification: Core
Product Description: apicoplast ribosomal protein S6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0070181 | small ribosomal subunit rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.96 |
| Trophozoite | not expressed | 0.60 | 0.66 |
| Schizont | not expressed | 0.22 | 0.86 |
| Gametocyte | not expressed | 0.34 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0932600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.891 | MFS: -2.519 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2J0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 13 | 4 | 11 |
| disruptive | 3 | 16 | 15 | 21 |
| missense | 2 | 16 | 14 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 22 | 6 | 18 |
| disruptive | 9 | 54 | 28 | 58 |
| missense | 4 | 33 | 20 | 39 |
PlasmoDB Total SNPs: 30
Non-coding: 19 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 247 | Molecular Weight (kDa): 29.798
UniProt ID(s): Q8I2J0
PDB ID(s): None
Isoelectric Point: 10.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000529 | Ribosomal protein S6 |
| InterPro | IPR020814 | Ribosomal protein S6, plastid/chloroplast |
| InterPro | IPR035980 | Ribosomal protein S6 superfamily |
| PFam | PF01250 | Ribosomal protein S6 |
| Superfamily | SSF54995 | Ribosomal protein S6 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |