PF3D7_0932700

Genome location: Pf3D7_09_v3:1,298,749..1,302,703(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.06	0.97
Trophozoite	no data	0.19	0.89
Schizont	no data	0.04	0.98
Gametocyte	no data	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0932700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.991 | MFS: -2.437 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2I9

"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=3.53) with 3IED (Global RMSD=15.97)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106130

Most Similar Human Ortholog: H7C1S4

TM-align score: 0.47 | RMSD: 2.70

Seq Identity: 0.09 | Length: 55 / 1236

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000159140	SON DNA and RNA binding protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	43	27	60
disruptive	44	165	97	191
missense	25	139	83	172

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	86	45	79
disruptive	88	309	142	283
missense	56	252	113	195

PlasmoDB Total SNPs: 198

Non-coding: 12 | Synonymous: 116 | Nonsynonymous: 69 | Stop Codon: 1

Protein Information

Protein Length: 1236 | Molecular Weight (kDa): 149.809

UniProt ID(s): Q8I2I9

PDB ID(s): None

Isoelectric Point: 9.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A