Genome location: Pf3D7_09_v3:1,302,916..1,308,589(-)
Genome classification: Core
Product Description: importin alpha re-exporter, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005635 | nuclear envelope |
| Function | GO:0005049 | nuclear export signal receptor activity |
| Process | GO:0006611 | protein export from nucleus |
| Process | GO:0006606 | protein import into nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.38 | 0.81 |
| Trophozoite | expressed | 0.77 | 0.58 |
| Schizont | expressed | 0.38 | 0.76 |
| Gametocyte | expressed | 0.69 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0932800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.159 | MFS: -3.143 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2I8
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.96) with 6JWQ (Global RMSD=16.63)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101888
Most Similar Human Ortholog: P55060
TM-align score: 0.76 | RMSD: 5.56
Seq Identity: 0.16 | Length: 907 / 1342
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000124207 | chromosome segregation 1 like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 66 | 44 | 96 |
| disruptive | 39 | 98 | 59 | 129 |
| missense | 12 | 67 | 51 | 106 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 37 | 148 | 54 | 88 |
| disruptive | 65 | 210 | 115 | 275 |
| missense | 28 | 147 | 88 | 184 |
PlasmoDB Total SNPs: 323
Non-coding: 206 | Synonymous: 83 | Nonsynonymous: 32 | Stop Codon: 2
Protein Length: 1342 | Molecular Weight (kDa): 159.114
UniProt ID(s): Q8I2I8
PDB ID(s): None
Isoelectric Point: 6.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005043 | Exportin-2, C-terminal |
| InterPro | IPR016024 | Armadillo-type fold |
| PFam | PF03378 | Exportin-2, C-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 34773052 | Unraveling the stepwise maturation of the yeast telomerase including a Cse1 andMtr10 mediated quality control checkpoint | Hirsch AG, Becker D, Lamping JP, Krebber H | 10.1038/s41598-021-01599-3 |
| 34575913 | CRISPR-Knockout of CSE Gene Improves Saccharification Efficiency by ReducingLignin Content in Hybrid Poplar | Jang HA, Bae EK, ..., Ko JH | 10.3390/ijms22189750 |
| 30341817 | Septin-associated proteins Aim44 and Nis1 traffic between the bud neck and thenucleus in the yeast Saccharomyces cerevisiae | Perez AM, Thorner J | 10.1002/cm.21500 |