Product Description: CSTF domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0098789 | pre-mRNA cleavage required for polyadenylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.70 | 0.66 |
| Trophozoite | expressed | 0.53 | 0.69 |
| Schizont | expressed | 0.42 | 0.74 |
| Gametocyte | expressed | 0.39 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0933000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.714 | MFS: -2.412 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0512600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I0W1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100265
Most Similar Human Ortholog: K7ENX8
TM-align score: 0.88 | RMSD: 1.22
Seq Identity: 0.25 | Length: 79 / 761
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000099622 | cold inducible RNA binding protein |
| ENSG00000101811 | cleavage stimulation factor subunit 2 |
| ENSG00000102317 | RNA binding motif protein 3 |
| ENSG00000177613 | cleavage stimulation factor subunit 2 tau variant |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 43 | 23 | 41 |
| disruptive | 25 | 82 | 54 | 134 |
| missense | 11 | 72 | 53 | 109 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 87 | 28 | 56 |
| disruptive | 45 | 205 | 127 | 243 |
| missense | 22 | 166 | 101 | 140 |
PlasmoDB Total SNPs: 157
Non-coding: 96 | Synonymous: 41 | Nonsynonymous: 19 | Stop Codon: 1
Protein Length: 761 | Molecular Weight (kDa): 88.928
UniProt ID(s): Q8I0W1
PDB ID(s): None
Isoelectric Point: 9.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR025742 | Cleavage stimulation factor subunit 2, hinge domain |
| InterPro | IPR031721 | Partial cleavage stimulation factor domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| PFam | PF14327 | Cleavage stimulation factor subunit 2, hinge domain |
| PFam | PF15861 | Partial cleavage stimulation factor domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |