PF3D7_0933100

Genome location: Pf3D7_09_v3:1,314,184..1,317,597(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.11	0.95
Trophozoite	not expressed	0.11	0.94
Schizont	not expressed	0.09	0.94
Gametocyte	expressed	0.60	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0933100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.123 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H585

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215346

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	38	34	61
disruptive	41	67	45	117
missense	22	54	33	100

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	88	48	54
disruptive	62	174	98	192
missense	27	126	83	132

PlasmoDB Total SNPs: 272

Non-coding: 190 | Synonymous: 53 | Nonsynonymous: 27 | Stop Codon: 2

Protein Information

Protein Length: 825 | Molecular Weight (kDa): 100.871

UniProt ID(s): C0H585

PDB ID(s): None

Isoelectric Point: 9.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A