Product Description: calcyclin-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Process | GO:0050821 | protein stabilization |
| Process | GO:0031647 | regulation of protein stability |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.06 | 0.97 |
| Trophozoite | possibly expressed | 0.39 | 0.77 |
| Schizont | possibly expressed | 0.14 | 0.91 |
| Gametocyte | not expressed | 0.34 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0933200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.205 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H586
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102530
Most Similar Human Ortholog: Q9Y2Z0
TM-align score: 0.44 | RMSD: 2.20
Seq Identity: 0.26 | Length: 96 / 200
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000165416 | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 10 | 3 | 10 |
| disruptive | 3 | 7 | 6 | 17 |
| missense | 3 | 6 | 6 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 15 | 10 | 5 |
| disruptive | 7 | 23 | 19 | 50 |
| missense | 6 | 15 | 12 | 32 |
PlasmoDB Total SNPs: 156
Non-coding: 148 | Synonymous: 3 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 200 | Molecular Weight (kDa): 23.999
UniProt ID(s): C0H586
PDB ID(s): None
Isoelectric Point: 5.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007052 | CS domain |
| InterPro | IPR007699 | SGS domain |
| InterPro | IPR008978 | HSP20-like chaperone |
| PFam | PF04969 | CS domain |
| PFam | PF05002 | SGS domain |
| Superfamily | SSF49764 | HSP20-like chaperone |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |