PF3D7_0933400

Genome location: Pf3D7_09_v3:1,323,597..1,324,805(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	expressed	0.43	0.74
Schizont	expressed	0.07	0.95
Gametocyte	expressed	0.43	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0933400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.935 | MFS: -2.94 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H588

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533445

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	14	6	8
disruptive	3	14	10	31
missense	3	14	10	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	21	7	20
disruptive	6	38	36	49
missense	4	30	34	41

PlasmoDB Total SNPs: 38

Non-coding: 27 | Synonymous: 9 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 268 | Molecular Weight (kDa): 32.015

UniProt ID(s): C0H588

PDB ID(s): None

Isoelectric Point: 10.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A